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PP2A-Cα/β Antibody (1D6): sc-80665

 |  Datasheet

(Based on data analysis)

  • PP2A-Cα/β Antibody (1D6) is a mouse monoclonal IgG2b provided at 100 µg/ml
  • raised against amino acids 295-309 of PP2A-Cα/β of human PP2A
  • recommended for detection of PP2A-Cα/β of mouse, rat, human, Xenopus and zebrafish origin by WB, IP, IF and IHC(P); to demethylate, treat with 100mM NaOH on ice; also reactive with additional species, including bovine, porcine and canine
 

See additional PP2 Antibodies including PP2, PP2A-B55-β , PP2A-B55-δ, PP2A-Cβ, PP2Comega, PP2A-A alpha, PP2A-A alpha / beta, PP2A-C , PP2A-C alpha, PP2A-C alpha / beta, PP2B-A, PP2B-A alpha, PP2B-A beta, PP2B-A gamma, PP2C alpha, PP2C alpha / beta, PP2C beta, PP2C epsilon, PP2C eta, PP2C gamma, PP2C kappa, PP2C zeta, PP2B-B1, PP2B-B2, PP2A-B55, PP2A-B55-alpha, PP2A-B55-gamma, PP2A-B56-alpha, PP2A-B56-beta, PP2A-B56-delta, PP2A-B56-gamma, PP2A-B72 and PP2A-B130.

Also see PP2 Inhibitors, PP2 Activators or PP2 Substrates for functional analysis of cellular responses to PP2.


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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
PP2A-Cα/β Antibody (1D6) sc-80665 100 µg/ml $279
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PP2A-Cα (h): 293T Lysate sc-114598 100 µg/200 µl $205
PP2A-Cβ (h): 293T Lysate sc-113470 100 µg/200 µl $205
PP2A-Cα (m): 293T Lysate sc-125847 100 µg/200 µl $205
PP2A-Cα (m2): 293T Lysate sc-125848 100 µg/200 µl $205
Hep G2 Cell Lysate sc-2227 500 µg/200 µl $104
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
MCF7 Whole Cell Lysate sc-2206 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PPP2CA 5515 5q31.1 NM_002715 P67775
 176915
Human PPP2CB 5516 8p12 NM_001009552, NM_004156 P62714
 176916
Mouse Ppp2ca 19052 11 B1.3 P63330
 N/A
Mouse Ppp2cb 19053 8 A4 P62715
 N/A
 

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit, and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A family comprises subfamily members PP2Aå and PP2A∫. The PP2A catalytic subunit associates with a variety of regulatory subunits. Regulatory subunits include PP2A-Aå and -A∫, PP2A-Bå and -B∫, PP2A-Cå and -C∫, and PP2A-B56å and -B56∫.
PP2A-Cα/β Antibody (1D6) Data
Click on image to enlarge
sc-80665
PP2A-Cα/β (1D6): sc-80665. Western blot analysis of PP2A-C expression in Hep G2 (A), K-562 (B) and HeLa (C) whole cell lysates.
sc-80665
PP2A-Cα/β (1D6): sc-80665. Western blot analysis of PP2A-Cβ expression in non-transfected: sc-117752 (A) and human PP2A-Cβ transfected: sc-113470 (B) 293T whole cell lysates.
sc-80665
PP2A-Cα/β (1D6): sc-80665. Western blot analysis of PP2A-Cα expression in non-transfected 293T: sc-117752 (A), human PP2A-Cα transfected 293T: sc-114598 (B) and MCF7 (C) whole cell lysates.
sc-80665
PP2A-C (1D6): sc-80665. Western blot analysis of PP2Aα expression in non-transfected: sc-117752 (A) and mouse PP2Aα transfected: sc-125847 (B) 293T whole cell lysates.
sc-80665
PP2A-Cα/β (1D6): sc-80665. Western blot analysis of PP2Aα expression in non-transfected 293T: sc-117752 (A), mouse PP2A-Cα transfected 293T: sc-125848 (B), A-673 (C) and MCF7 (D) whole cell lysates.
sc-80665
Western blot analysis of PP2A-Cα/β phosphorylation in untreated (A,D), EGF treated (B,E) and EGF and Alkaline phosphatase treated (C,F) HeLa whole cell lysates. Antibodies tested include p-PP2A-Cα/β (TF-8): sc-271903 (A,B,C) and PP2A-Cα/β (1D6): sc-80665 (D,E,F).
sc-80665
Western blot analysis of PP2A-Cα/β phosphorylation in untreated (A,D), EGF treated (B,E) and EGF and Alkaline phosphatase treated (C,F) HeLa whole cell lysates. Antibodies tested include p-PP2A-Cα/β (Tyr 307)-R: sc-12615-R (A,B,C) and PP2A-Cα/β (1D6): sc-80665 (D,E,F).
sc-80665
Western blot analysis of PP2A-C&alphla;/β phosphorylation in untreated (A,C) and EGF treated (B,D) HeLa whole cell lysates. Antibodies tested include p-PP2A-C&alphla;/β (Tyr 307)-R: sc-12615-R (A,B) and PP2A-C&alphla;/β (1D6): sc-80665 (C,D).
sc-80665
Western blot analysis of PP2A-C&alphla;/β phosphorylation in untreated (A,C) and EGF treated (B,D) HeLa whole cell lysates. Antibodies tested include p-PP2A-C&alphla;/β (F-8): sc-271903 (A,B) and PP2A-C&alphla;/β (1D6): sc-80665 (C,D).
sc-80665
Western blot analysis of PP2A-C&alphla;/β phosphorylation in untreated (A,C) and EGF treated (B,D) HeLa whole cell lysates. Antibodies tested include p-PP2A-C&alphla;/β (D-6): sc-271904 (A,B) and PP2A-C&alphla;/β (1D6): sc-80665 (C,D).
sc-80665
PP2A-Cα/β (1D6): sc-80665. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of glandular cells.
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