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home » Neurobiology » Doublecortin Antibody / Doublecortin Antibodies » Doublecortin (C-18): sc-8066

Doublecortin (C-18) Antibody: sc-8066

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping at the C-terminus of Doublecortin of human origin
  • recommended for detection of Doublecortin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-8066 P
 
Additional Doublecortin Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human DCX 1641 Xq22.3 NM_000555, NM_178151, NM_178152, NM_178153 O43602
 300121
Mouse Dcx 13193 X F2 O88809
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Doublecortin (C-18) sc-8066 200 µg/ml $279
Doublecortin (C-18) P sc-8066 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Doublecortin siRNA (h) sc-35214 10 µM $258
Doublecortin siRNA (m) sc-35215 10 µM $258
Doublecortin (h)-PR sc-35214-PR 10 µM $23
Doublecortin (m)-PR sc-35215-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Doublecortin shRNA Plasmid (h) sc-35214-SH 20 µg $520
Doublecortin shRNA Plasmid (m) sc-35215-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Doublecortin shRNA (h) Lentiviral Particles sc-35214-V 200 µl $625
Doublecortin shRNA (m) Lentiviral Particles sc-35215-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
SK-N-SH Cell Lysate sc-2410 500 µg/200 µl $104
Doublecortin (h): 293T Lysate sc-114231 100µg/200µl $205

Doublecortin Background Information
Lissencephaly (smooth brain) is an abnormality of brain development characterized by incomplete neuronal migration and a smooth cerebral surface, resulting in severe mental retardation. Genetic analysis identified two proteins that are mutated in some cases of lissencephaly, designated lissencephaly-1 protein (LIS1) and doublecortin. LIS1 shows sequence homology to ß-subunits of heterotrimeric G proteins. Doublecortin contains a consensus Abl phosphorylation site, and it has some sequence homology to a predicted kinase protein. Both proteins are highly expressed in developing brain, suggesting that they may be involved in a signal transduction pathway that is crucial to brain development.

Doublecortin (C-18) Product Citations
See how others have used Doublecortin (C-18): sc-8066 antibody and or Doublecortin (C-18) antibody conjugates.


116 total citations
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Doublecortin (C-18)
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sc-8066
Doublecortin (C-18): sc-8066. Western blot analysis of Doublecortin expression in SK-N-SH whole cell lysate (A) and mouse embryo extract (B).
sc-8066
Doublecortin (C-18): sc-8066. Immunofluorescence staining of methanol-fixed SK-N-SH cells showing cytoplasmic localization.
sc-8066
Doublecortin (C-18): sc-8066. Immunofluorescence staining of Doublecortin (red) and Neu N (green) in dentate gyrus of seven day post-ischemic rat brain perfused with 4% paraformaldehyde at low magnification (A,C,E) and thin optical sections (~1 µm) under high magnification (B,D,F) demonstrating that doublecortin identifies newly formed neurons. Kindly provided by Dr. Dan Small and Dr. Robert Monette from the Institute for Biological Sciences, National Research Council, Ottawa, Canada.
sc-8066
Doublecortin (C-18): sc-8066. Western blot analysis of Doublecortin expression in 3T3-L1 whole cell lysate.
sc-8066
Doublecortin (C-18): sc-8066. Western blot analysis of Doublecortin expression in non-transfected 293T: sc-117752 (A), human Doublecortin transfected 293T: sc-114231 (B) and SK-N-SH (C) whole cell lysates.
sc-8066
Doublecortin (C-18): sc-8066. Western blot analysis of Doublecortin expression in IMR-32 whole cell lysate.
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