raised against full length native Mesotrypsinogen from pancreatic tissue of human origin
recommended for detection of trypsin, trypsinogen and trypsin in complex with α 1 antitrypsin of human origin by WB and ELISA; also reactive with additional species, including bovine
Mesotrypsinogen Background Information Mesotrypsinogen is an isoform of human Trypsin, belonging to the Trypsin family of serine proteases. Mesotrypsinogen is known to be resistant to common Trypsin inhibitors such as SBTI and SPINK1, which may contribute to pathogenesis of pancreatitis by reducing the protective levels of SPINK1 in the pancreas. A minor pancreatic digestive enzyme that degrades dietary Trypsin inhibitors in the gut, Measotrypsinogen may function to facilitate the digestion of foods rich in natural Trypsin inhibitors. Mesotrypsinogen migrates to the brain and pancreas and operates on peptide linkages involving the carboxyl group of lysine or Arginine. The gene encoding the Mesotrypsinogen protein maps to the locus of T cell receptor b variable orphans on chromosome 9.
