Dvl-1 (3F12) Antibody: sc-8025

Dvl-1 Background Information
Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3 (1-5). The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein (1,2). Like their Drosophila counterpart, the dishevelled proteins are thought to be involved in embryogenesis (5). Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3ß. This finding may prove to be important in Alzheimer’s studies, which have shown that tau is hyperphosphorylated (6). In Drosophila, Dsh is a component of the frizzled signaling pathway (7). Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway (8).