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home » Neurobiology » Trk Antibody / Trk Antibodies » p-Trk (Tyr 680/Tyr 681): sc-7996

p-Trk (Tyr 680/Tyr 681) Antibody: sc-7996

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-7996-R
  • epitope corresponding to an amino acid sequence containing phosphorylated Tyr 680 and Tyr 681 of Trk A of human origin (identical to corresponding Trk B sequence; differs from corresponding Trk C sequence by three amino acids)
  • recommended for detection of Tyr 680/Tyr 681 phosphorylated Trk A and correspondingly phosphorylated Trk B; partially cross-reactive with correspondingly phosphorylated Trk C by mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-7996 P
 
Additional Trk Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NTRK1 4914 1q23.1 NM_001007792, NM_001012331, NM_002529 P04629
 256800
Mouse Ntrk1 18211 3 F1 Q3UFB7
 N/A
Mouse Ntrk2 18212 13 B1 P15209
 N/A
Mouse Ntrk3 18213 7 D3 Q6VNS1
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-Trk (Tyr 680/Tyr 681) sc-7996 200 µg/ml $279
p-Trk (Tyr 680/Tyr 681) P sc-7996 P
(peptide)
 100 µg/0.5 ml $61
p-Trk (Tyr 680/Tyr 681)-R sc-7996-R 200 µg/ml $279
Lambda Phosphatase sc-200312 100,000 units $462
Lambda Phosphatase sc-200312A 20,000 units $116
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Trk siRNA (h) sc-29511 10 µM $258
Trk siRNA (m) sc-29512 10 µM $258
Trk (h)-PR sc-29511-PR 10 µM $23
Trk (m)-PR sc-29512-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Trk shRNA Plasmid (h) sc-29511-SH 20 µg $520
Trk shRNA Plasmid (m) sc-29512-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Trk shRNA (h) Lentiviral Particles sc-29511-V 200 µl $625
Trk shRNA (m) Lentiviral Particles sc-29512-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
RAW 264.7 Whole Cell Lysate sc-2211 500 µg/200 µl $104
mouse brain extract sc-2253 500 µg/200 µl $104

Trk Background Information
The Trk proto-oncogene encodes a membrane-spanning protein tyrosine kinase, Trk gp140, also designated Trk A, whose expression is restricted in vivo to neurons of the sensory spinal and cranial ganglia of neural crest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia. Tyrosine phosphorylation of Trk by NGF is rapid, specific and occurs with picomolar quantities of factor, indicating that the response is mediated by physiological amounts of NGF. Unlike Trk A, tyrosine phosphorylation of Trk B is induced by the brain-derived neurotrophic factor (BDNF) and, to a lesser extent, neurotrophin-3 (NT-3). Additionally, Trk C phosphorylation is induced via interaction with endogenously produced NT-3 and is not dependent on stimulation by NGF.

p-Trk (Tyr 680/Tyr 681) Product Citations
See how others have used p-Trk (Tyr 680/Tyr 681): sc-7996 antibody and or p-Trk (Tyr 680/Tyr 681) antibody conjugates.


6 total citations
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p-Trk (Tyr 680/Tyr 681)
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sc-7996
p-Trk (Tyr 680/Tyr 681)-R: sc-7996-R. Western blot analysis of Trk phosphorylation in untreated (A) and lambda protein phosphatase treated (B) mouse brain tissue extracts.
sc-7996
Western blot analysis of Trk phosphorylation in untreated (A, C) and lambda protein phosphatase treated (B, D) RAW 264.7 whole cell lysates. Antibodies tested include p-Trk (Tyr 680/Tyr 681)-R: sc-7996-R (A, B) and Trk (C-15): sc-139 (C, D).
sc-7996
Western blot analysis of Trk phosphorylation in untreated (A, C) and lambda protein phosphatase treated (B, D) Ramos whole cell lysates. Antibodies tested include p-Trk (Tyr 680/Tyr 681)-R: sc-7996-R (A, B) and Trk (C-15): sc-139 (C, D).
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