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p-Stat3 (Tyr 705) Antibody: sc-7993 |
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- goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-7993-R
- recommended for detection of Stat3 of mouse, rat and human origin phosphorylated at Tyr 705 by WB, IP, IF and ELISA
- blocking peptide, sc-7993 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-7993 X, 200 µg/0.1 ml
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Stat3 Background Information
Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3∫ appears to be activated by both while Stat3å is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
| p-Stat3 (Tyr 705) Product Citations |
See how others have used p-Stat3 (Tyr 705): sc-7993 antibody and or p-Stat3 (Tyr 705) antibody conjugates.
51 total citations Loading citations.
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p-Stat3 (Tyr 705)
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Western blot analysis of Stat3 phosphorylation in untreated (A) and IFN-α-treated (B) SK-MEL-28 cell cultures. Lanes A,B probed, respectively, with Stat3 antibody, sc-8019 or with phospho-Stat3 antibody, sc-7993. p-Stat3 (Tyr 705)-R: sc-7993-R. Western blot analysis of phosphorylated Stat3 expression in HeLa (A), IFN-α-treated HeLa (B), SK-MEL-28 (C) and IFN-α-treated Sk-MEL-28 (D) whole cell lysates.
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