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home » Transcription Regulators » Stat Antibody / Stat Antibodies » p-Stat1 (Tyr 701): sc-7988

p-Stat1 (Tyr 701) Antibody: sc-7988

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-7988-R
  • recommended for detection of Stat1 of mouse, rat, human and Xenopus origin phosphorylated at Tyr 701 by WB, IP, IF and ELISA
  • blocking peptide, sc-7988 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-7988 X, 200 µg/0.1 ml
  • for phosphorylation positive (sc-2222) and non-activated control (sc-2200) cell extracts
 
Additional Stat Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human STAT1 6772 2q32.2 NM_007315, NM_139266 P42224
 600555
Mouse Stat1 20846 1 C1.1 P42225
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-Stat1 (Tyr 701) sc-7988 200 µg/ml $279
p-Stat1 (Tyr 701) P sc-7988 P
(peptide)
 100 µg/0.5 ml $61
p-Stat1 (Tyr 701) X sc-7988 X 200 µg/0.1 ml $279
p-Stat1 (Tyr 701)-R sc-7988-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Stat1 p84/p91 siRNA (h) sc-44123 10 µM $258
Stat1 p84/p91 siRNA (m) sc-44124 10 µM $258
Stat1 p84/p91 (h)-PR sc-44123-PR 10 µM $23
Stat1 p84/p91 (m)-PR sc-44124-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Stat1 p84/p91 shRNA Plasmid (h) sc-44123-SH 20 µg $520
Stat1 p84/p91 shRNA Plasmid (m) sc-44124-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Stat1 p84/p91 shRNA (h) Lentiviral Particles sc-44123-V 200 µl $625
Stat1 p84/p91 shRNA (m) Lentiviral Particles sc-44124-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa + IFN-γ Cell Lysate sc-2222 500 µg/200 µl $104

Stat1 Background Information
Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors (1,2). Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex (3). Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3∫ appears to be activated by both while Stat3å is activated by EGF, but not by IL-6 (4,5). Highest expression of Stat4 is seen in testis and myeloid cells (6). IL-12 has been identified as an activator of Stat4 (2). Stat5 has been shown to be activated by prolactin and by IL-3 (7). Stat6 is involved in IL-4 activated signaling pathways (8).

p-Stat1 (Tyr 701) Product Citations
See how others have used p-Stat1 (Tyr 701): sc-7988 antibody and or p-Stat1 (Tyr 701) antibody conjugates.


30 total citations
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p-Stat1 (Tyr 701)
Click on image to enlarge
sc-7988
Western blot detection of Stat1 phosphorylation using untreated (A,C) and IFN-γ-treated (B,D) HeLa cells. Antibodies tested include p-Stat1 (Tyr 701): sc-7988-R (A,B) and Stat1α p91 (C-111): sc-417 (C,D).
sc-7988
p-Stat1 (Tyr 701): sc-7988. Immunofluorescence staining of methanol-fixed, γ-interferon-treated HeLa cells, showing nuclear localization of activated Stat1.
sc-7988
Western blot analysis of Stat1 phosphorylation in untreated (A,C) and IFN-γ-treated (B,D) SK-MEL-28 cell cultures. Lanes A,B and C,D probed, respectively, with Stat1α p91 (C-111): sc-417 (A,B) or with p-Stat1 (Tyr 701): sc-7988 (C,D).
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