goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-7979-R
epitope corresponding to a short amino acid sequence containing phosphorylated Ser 383 of Elk-1 of human origin
reactive with Ser 383 phosphorylated Elk-1 and, to a lesser extent, with correspondingly phosphorylated SAP-1 of mouse, rat and human origin by WB, IP, IF and ELISA
blocking peptide, sc-7979 P
TransCruz reagent for Gel Supershift and ChIP applications sc-7979 X, 200 µg/0.1 ml
Elk-1 Background Information Members of the Ets gene family exhibit varied patterns of tissue expression and share a highly conserved carboxy terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. This conserved domain is essential for Ets-1 binding to DNA and is likely responsible for the DNA binding activity of all members of the Ets gene family. ELK-1 is a 428 amino acid nuclear protein belonging to the Ets family. Expressed in lung and testis, ELK-1 stimulates transcription and binds to purine-rich DNA sequences. Upon mitogenic stimulation, ELK-1 is phosphorylated on C-terminal serine and threonine residues by MAPK1 (mitogen-activated protein kinase 1). Phosphorylation of ELK-1 leads to loss of SUMOylation and restores transcriptional activator activity. SUMOylation of ELK-1 results in recruitment of HDAC2 to target gene promoters, which leads to decreased histone acetylation and reduced transactivator activity.
p-Elk-1 (Ser 383) Product Citations
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p-Elk-1 (Ser 383)
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p-Elk-1 (Ser 383)-R: sc-7979-R. Western blot analysis of Elk-1 phosphorylation in untreated (A), UV irradiated (B) and UV irradiated and lambda protein phosphatase treated (C) HeLa whole cell lysates.
