ARF6 Background Information The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF-dependent regulatory mechanisms include the coordination of spectrin interactions with golgi membranes and the association
of Actin to the Golgi via rho family-dependent G-protein localization (Rac, CDC42) and WASP/Arp2/3 complexes. Additionally, ARFs play a central role in maintenance of organelle integrity, assembly of coat proteins and activation of phospholipase D. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6); members of each class share a common gene organization. The human ARF6 gene contains five exons and four introns, and encodes a 175 amino acid protein.
ARF6 (3A-1) Product Citations
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ARF6 (3A-1)
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ARF6 (3A-1): sc-7971. Western blot analysis of ARF6 expression in KNRK whole cell lysate.
ARF6 (3A-1): sc-7971. Western blot analysis of ARF6 expression in non-transfected: sc-117752 (A) and mouse ARF6 transfected: sc-118516 (B) 293T whole cell lysates.
ARF6 (3A-1): sc-7971. Western blot analysis of ARF6 expression in non-transfected 293T: sc-117752 (A), mouse ARF6 transfected 293T: sc-118517 (B), HeLa (C) and Caki-1 (D) whole cell lysates.
ARF6 (3A-1): sc-7971. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing cytoplasmic staining of glandular cells.
