epitope mapping within an internal region of VDAC3 of human origin
recommended for detection of VDAC3 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
VCAC3 Background Information Adenine nucleotide translocator (ANT) and the voltage-dependent anion-selective channel proteins 1, 2 and 3 (VDAC1, VDAC2 and VDAC3) are components of the permeability transition pore complex (PTPC) of the mitochondrial inner or outer membranes. Formation of PTPCs, the subsequent dissipation of mitochondrial inner membrane potential and release of cytochrome c through the outer mitochondrial membrane are critical events in the early stages of apoptosis. Bax, a proapoptotic protein, has been shown to act upon ANT to induce the dissipation of mitochondrial inner membrane potential.
