epitope mapping at the C-terminus of GADD 45α of human origin
recommended for detection of GADD 45α of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
GADD 45α Background Information It is well established that cell cycle progression is subject to arrest at G1 and G2 checkpoints in response to DNA damage, presumably to allow time for DNA repair prior to entry into S and M phase, respectively. The p53 tumor suppressor is required for one such G1 checkpoint and functions to upregulate expression of GADD 45 and p21. p21 functions to inhibit the kinase activity of multiple Cdk complexes, which may account for its suppression of cell growth. GADD 45 binds both Cdks and PCNA, a protein involved in DNA replication and repair. GADD 45 has been shown to stimulate DNA excision repair in vitro and to inhibit entry of cells into S phase. Thus, it has been suggested that GADD 45 may serve as a link between p53-dependent cell cycle checkpoint and DNA repair .
GADD 45α (C-20) Product Citations
See how others have used GADD 45α (C-20): sc-792 antibody and or GADD 45α (C-20) antibody conjugates.
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GADD 45α (C-20)
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Western blot analysis of COS cells transfected with GADD 45α (A,B). Antibodies tested include GADD 45α (C-20): sc-792 (A) and GADD 45α (H-165): sc-797 (B).
