IL-16 (H-110) Antibody: sc-7902

IL-16 Background Information
Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, intiate signal transduction cascades that elicit physiological changes in their target cells. Interleukin-16, or IL-16, is a cytokine that has chemoattractant activity on CD4+ T lymphocytes. It has long been known that eosinophils and CD4+ T lymphocytes are recruited to sites of allergic inflammation, but the molecular mechanism was poorly understood. IL-16, also referred to as lymphocyte chemoattractant factor, is secreted by activated eosinophils as part of the allergic response along with RANTES, an additional cytokine (7). Once bound to its cognate receptor, CD4, IL-16 initiates a signal cascade that results in the activation of the PKC family.