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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 435-488 mapping at the C-terminus of HDAC2 of human origin
- recommended for detection of HDAC2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- TransCruz reagent for ChIP application, sc-7899 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
HDAC2 |
3066 |
6q22.1 |
NM_001527 |
Q92769
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605164 |
| Mouse |
Hdac2 |
15182 |
10 B1 |
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P70288
|
N/A |
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HDAC2 Background Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation, and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1) and HDAC2 (also designated mammalian RPD3), both of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.
| HDAC2 (H-54) Product Citations |
See how others have used HDAC2 (H-54): sc-7899 antibody and or HDAC2 (H-54) antibody conjugates.
78 total citations Loading citations.
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HDAC2 (H-54)
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HDAC2 (H-54): sc-7899. Immunoperoxidase staining of formalin-fixed, paraffin-embedded mouse liver tissue showing nuclear localization.
HDAC2 (H-54): sc-7899. Western blot analysis of HDAC2 expression in K-562 (A), phorbol-induced Jurkat (B) and NIH/3T3 (C) nuclear extracts and mouse testis extract (D).
HDAC2 (H-54): sc-7899. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing nuclear staining.
HDAC2 (H-54): sc-7899. Western blot analysis of HDAC2 expression in HeLa whole cell lysate.
HDAC2 (H-54): sc-7899. Immunoperoxidase staining of formalin fixed, paraffin-embedded human brain tissue showing nuclear and cytoplasmic staining of neuronal cells.
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