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home » Cell Cycle Proteins » Chk Antibody / Chk Antibodies » Chk1 (FL-476): sc-7898

Chk1 (FL-476) Antibody: sc-7898

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 1-476 representing full length Chk1 of human origin
  • recommended for detection of Chk1 of mouse, rat, human and Xenopus origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, bovine and porcine
  • agarose conjugate for IP studies, sc-7898 AC, 500 µg/0.25 ml agarose
  • fluorescein (sc-7898 FITC) and rhodamine (sc-7898 TRITC) conjugates for immunofluorescence, 200 µg/ml
  • Alexa Fluor® 405 (sc-7898 AF405), Alexa Fluor® 488 (sc-7898 AF488) and Alexa Fluor® 647 (sc-7898 AF647) conjugates for immunofluorescence; 100 µg/2 ml
 
Additional Chk Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CHEK1 1111 11q24.2 NM_001274 O14757
 603078
Mouse Chek1 12649 9 A4 O35280
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Chk1 (FL-476) sc-7898 200 µg/ml $279
Chk1 (FL-476) AC sc-7898 AC 500µg/ml, 25%ag $366
Chk1 (FL-476) Alexa Fluor® 405 sc-7898 AF405 100 µg/2 ml $314
Chk1 (FL-476) Alexa Fluor® 488 sc-7898 AF488 100 µg/2 ml $314
Chk1 (FL-476) Alexa Fluor® 647 sc-7898 AF647 100 µg/2 ml $314
Chk1 (FL-476) FITC sc-7898 FITC 200 µg/ml $282
Chk1 (FL-476) TRITC sc-7898 TRITC 200 µg/ml $282
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Chk1 siRNA (h) sc-29269 10 µM $258
Chk1 siRNA (m) sc-29270 10 µM $258
Chk1 (h)-PR sc-29269-PR 10 µM $23
Chk1 (m)-PR sc-29270-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Chk1 shRNA Plasmid (h) sc-29269-SH 20 µg $520
Chk1 shRNA Plasmid (m) sc-29270-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Chk1 shRNA (h) Lentiviral Particles sc-29269-V 200 µl $625
Chk1 shRNA (m) Lentiviral Particles sc-29270-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104

Chk1 Background Information
Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved in these processes as regulators of Cdks. Chk1 and Chk2 both function as essential components in the G2 DNA damage checkpoint by phosphorylating Cdc25C in response to DNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown that Chk1 can phosphorylate Wee1 in vitro, providing evidence that the hyperphosphorylated form of Wee1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation by Chk1.

Chk1 (FL-476) Product Citations
See how others have used Chk1 (FL-476): sc-7898 antibody and or Chk1 (FL-476) antibody conjugates.


46 total citations
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Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
 
Chk1 (FL-476)
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sc-7898
Chk1 (FL-476): sc-7898. Western blot analysis of Chk1 expression in HeLa (A), K-562 (B) and NIH/3T3 (C) whole cell lysates.
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