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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 432-482 of HDAC1 of human origin
- recommended for detection of HDAC1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- TransCruz reagent for ChIP application, sc-7872 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
HDAC1 |
3065 |
1p35.1 |
NM_004964 |
Q13547
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601241 |
| Mouse |
Hdac1 |
433759 |
4 D2.2 |
|
O09106
|
N/A |
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HDAC1 Background Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.
| HDAC1 (H-51) Product Citations |
See how others have used HDAC1 (H-51): sc-7872 antibody and or HDAC1 (H-51) antibody conjugates.
111 total citations Loading citations.
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HDAC1 (H-51)
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HDAC1 (H-51): sc-7872. Western blot analysis of HDAC1 expression in NIH/3T3 (A), HeLa (B), KNRK (C) and C32 (D) nuclear extracts.
ChIP analysis of transcription regulatory proteins associated with the Pitx2 promoter in aT3-1 cells in response to lithium. Antibodies tested include LEF-1 (C-19): sc-8592 amd LEF-1 (N-17): sc-8591 (B), β-catenin (H-102): sc-7199, β-catenin (C-18): sc-1496 and β-catenin (E-5): sc-7963 (C), HDAC1 (H-11): sc-7872, HDAC1 (C-19): sc-6298 and HDAC1 (H-11): sc-8410 (D), HDAC2 (C-8): sc-9959, HDAC2 (H-54): sc-7899 and HDAC2 (C-19): sc-6296 (E). Input control (A). Data kindly provided by M.G. Rosenfeld and reproduced with permission from Kioussi et al., Cell 2002, 111: 673-685.
ChIP analysis of c-Myc promoter occupancy in response to lithium stimulation in serum synchronized C2C12 cells. Antibodies tested include HDAC1 (H-15): sc-7872, HDAC1 (C-19): sc-6298 and HDAC1 (H-11): sc-8410 (A), β-catenin (H-120): sc-7199, β-catenin (C-18): sc-1496 and β-catenin (E-5): sc-7963 (B), E2F-4 (A-20): sc-1082, E2F-4 (D-3): sc-6851, E2F-4 (RK-13): sc-511 and E2F-4 (C-20): sc-866 (C), and p130 (C-20): sc-317, p130 (211.6): sc-9963 and p130 (H-125): sc-20678 (D). Data kindly provided by M.G. Rosenfeld and reproduced with permission from Proc. Natl. Acad. Sci. 100: 3245-3250. Copyright 2003 National Academy of Sciences, USA. HDAC1 (H-51): sc-7872. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
HDAC1 (H-51): sc-7872. Western blot analysis of HDAC1 expression in non-transfected 293T: sc-117752 (A), mouse HDAC1 transfected 293T: sc-125435 (B) and Hep G2 (C) whole cell lysates. HDAC1 (H-51): sc-7872. Western blot analysis of HDAC1 expression in non-transfected: sc-117752 (A) and human HDAC1 transfected: sc-172014 (B) 293T whole cell lysates. HDAC1 (H-51): sc-7872. Western blot analysis of HDAC1 expression in non-transfected: sc-117752 (A) and human HDAC1 transfected: sc-171441 (B) 293T whole cell lysates. |
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