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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of BLM of human origin
- recommended for detection of BLM of human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-7790 P
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
BLM |
641 |
15q26.1 |
NM_000057 |
P54132
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604610 |
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BLM Background Information
Bloom’s syndrome is an autosomal recessive disorder characterized by pre- and post-natal growth deficiencies, sun sensitivity, immunodeficiency and a predisposition to various cancers. The gene responsible for Bloom’s syndrome, BLM, encodes a protein homologous to the RecQ helicase of E. coli and is mutated in most Bloom’s syndrome patients. One characteristic of Bloom’s syndrome is an increased frequency of sister chromatid exchange (SCE). BLM has been shown to unwind G4 DNA, and a failure of this function is thought to be responsible for the increased rate of SCE. BLM is known to be translocated to the nucleus, where its ATPase activity is stimulated by both single- and double-stranded DNA. Mutations in the yeast SGS1, a homolog of BLM, are known to cause mitotic hyperrecombination similiar to that observed in Bloom’s cells.
| BLM (C-18) Product Citations |
See how others have used BLM (C-18): sc-7790 antibody and or BLM (C-18) antibody conjugates.
13 total citations Loading citations.
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BLM (C-18)
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BLM (C-18): sc-7790. Western blot analysis of BLM expression in K-562 nulear extract.
BLM (C-18): sc-7790. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
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