goat polyclonal IgG, 200 µg/ml epitope mapping at the N-terminus of γ-SNAP of human origin recommended for detection of γ-SNAP of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian blocking peptide, sc-7772 P
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Species
Gene Name
Gene ID
Chromosome Location
Isoform (mRNA) Accession #
Protein Accession #
OMIM™ Number
Human
NAPG
8774
18p11.22
NM_003826
Q99747
603216
γ-SNAP Background Information Syntaxins were originally thought to be docking proteins, but have now been categorized as anchoring proteins that anchor themselves to the cytoplasmic surfaces of cellular membranes. Syntaxins have been shown to bind to various proteins involved in exocytosis, including VAMPs (vesicle-associated membrane proteins), NSF (N-ethylmaleimide-sensitive factor), SNAP 25, SNAPs (soluble NSF attachment proteins) and synaptotagmin. VAMPs, also designated synaptobrevins, including VAMP-1 and VAMP-2, and synaptotagmin, a protein that may function as an inhibitor of exocytosis, are vesicular proteins. SNAPs, including å- and ©-SNAP, are cytoplasmic proteins that bind to a membrane receptor complex composed of VAMP, SNAP 25 and syntaxin. SNAPs mediate the membrane binding of NSF, which is essential for membrane fusion reactions. An additional protein designated synaptophysin may regulate exo-cytosis by competing with SNAP 25 and syntaxins for VAMP binding.