epitope mapping to a domain common to the C-terminus of UCP3L and UCP3S of human origin
recommended for detection of UCP3L and UCP3S of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA; also reactive with additional species, including equine and canine
UCP3 Background Information The uncoupling protein UCP1 (formerly designated UCP) is an integral membrane protein unique to brown adipose tissue mitochondria. UCP1 forms a dimer that acts as a proton channel, which can uncouple oxidative phosphorylation by dissipating the electrochemical potential across the inner mitochondrial membrane. This process induces heat production in brown adipose tissue and is involved in regulation of body temperature and glucose metabolism. UCP2 is a structurally related protein that also uncouples mitochondrial respiration. It is more widely expressed in human and mouse tissues, including white adipose tissue and muscle, than is UCP1. UCP2 is thought to play a role in body weight regulation. An additional UCP family member, UCP3, is highly muscle specific and is possibly involved in the uncoupling of oxidative phosphorylation in skeletal muscle.
UCP3 (C-20) Product Citations
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UCP3 (C-20)
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UCP3 (C-20): sc-7756. Western blot analysis of UCP3 expression in rat skeletal muscle (A) and mouse heart (B) tissue extracts.
