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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 1-454 representing full length RARγ of human origin
- recommended for detection of RARγ, RARβ and RARα of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications, sc-773 X, 200 µg/0.1 ml
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RAR Background Information
Retinoids are metabolites of vitamin A (retinol) that are important signaling molecules during vertebrate development and tissue differentiation. Retinoic acid receptors (RARs) and retinoid X receptors (RXRs) are nuclear transcription factors that modulate the effects of retinoids (RA) on gene expression. Most retinoid forms (including all trans RA, 9-cis RA, 4oxo RA and 3,4 dihydro RA) activate RAR family members, whereas RXR family members are activated by 9-cis-RA only. RA binds RARs, inducing a change in receptor configuration that allows DNA binding and increased gene transcription from specific genes to occur. RAR family members, which include RARå, RAR∫ and RAR©, belong to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor.
| RAR (M-454) Product Citations |
See how others have used RAR (M-454): sc-773 antibody and or RAR (M-454) antibody conjugates.
12 total citations Loading citations.
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RAR (M-454)
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Western blot analysis of RAR expression in NIH/3T3 (A) and K-562 (B) nuclear extracts. Antibodies tested include RAR (M-454): sc-773 (A) and RARγ (C-19): sc-550 (B). |
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