epitope mapping at the C-terminus of Villin of human origin
recommended for detection of Villin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine, bovine and porcine
Villin Background Information Caldesmon, Filamin 1, Nebulin and Villin are differentially expressed and regulated Actin binding proteins. Both muscular (CDh) and non-muscular (CDl) forms of Caldesmon have been identified and each has been shown to bind to Actin as well as to calmodulin and myosin. CDh is expressed predominantly on thin filaments in smooth muscle, whereas CDl is widely expressed in non-muscle tissues and cells. Filamin 1, which is ubiquitously expressed and exists as a homodimer, functions to crosslink Actin to filaments. Nebulin is a large filamentous protein specific to muscle tissue that may function as a ruler for filament length. Several isoforms of Nebulin are produced by alternative exon usage. Villin is Ca2+-regulated and is the major structural component of the brush border of absorptive cells.
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Villin (C-19)
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Villin (C-19): sc-7672. Immunoperoxidase staining of formalin-fixed, paraffin-embedded normal human skin showing localization within the cytoplasm.
Villin (C-19): sc-7672. Western blot analysis of Villin expression in mouse kidney extract.
Villin (C-19): sc-7672. Western blot analysis of Villin expression in non-transfected: sc-117752 (A) and mouse Villin transfected: sc-124565 (B) 293T whole cell lysates.
