epitope mapping at the C-terminus of Fes of human origin
recommended for detection of Fes of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and feline
Fes Background Information Fes, a tyrosine kinase encoded by the proto-oncogene c-fes, is expressed in macrophages and is thought to be involved in the regulation of myeloid differentiation. Fes has several characteristics typical of a cytoplasmic class of protein tyrosine kinases, including an SH2 domain and autophosphorylation capabilities. Fes has been shown to associate with IL-4 and several hematopoietic cytokine receptors, as well as with BCR. Phosphorylation of BCR by Fes induces the association of BCR with the Ras guanine nucleotide exchange factor complex GRB2/Sos.
Fes (C-19) Product Citations
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Fes (C-19)
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Fes (C-19): sc-7670. Western blot analysis of Fes expression in rat heart extract.
Fes (C-19): sc-7670. Western blot analysis of Fes expression in THP-1 whole cell lysate.
Fes (C-19): sc-7670. Western blot analysis of Fes expression in non-transfected: sc-117752 (A) and human Fes transfected: sc-114396 (B) 293T whole cell lysates.
Fes (C-19): sc-7670. Western blot analysis of Fes expression in non-transfected 293T: sc-117752 (A), human Fes transfected 293T: sc-159705 (B) and THP-1 (C) whole cell lysates.
Fes (C-19): sc-7670. Western blot analysis of Fes expression in HL-60 whole cell lysate.