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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 1-262 of c-Myc of human origin (includes transcriptional activation region, but not the bHLH-Zip protein-protein interaction domain)
- recommended for detection of c-Myc p67 of mouse, rat, human and monkey origin by WB, IP, IF and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications, sc-764 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
MYC |
4609 |
8q24.21 |
NM_002467 |
P01106
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190080 |
| Mouse |
Myc |
17869 |
15 D1 |
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P01108
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N/A |
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c-Myc Background Information c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half lives. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. The L-Myc gene has been reported to be amplified and expressed at high level in human small cell lung carcinomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region provided initial evidence for a sequence-specific binding function. A basic region helix-loop-helix leucine zipper motif (bHLH-Zip) protein, designated Max, specifically associates with c-Myc, N-Myc and L-Myc proteins. The Myc-Max complex binds to DNA in a sequence-specific manner under conditions where neither Max nor Myc exhibit appreciable binding. Max can also form heterodimers with at least two additional bHLH-Zip proteins, Mad and Mxi1, and Mad-Max dimers have been shown to repress transcription through interaction with mSin3.
| c-Myc (N-262) Product Citations |
See how others have used c-Myc (N-262): sc-764 antibody and or c-Myc (N-262) antibody conjugates.
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c-Myc (N-262)
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Western blot analysis of human recombinant c-Myc fusion protein untreated (A,C) or phosphorylated by p38α (B,D). Antibodies tested include c-Myc (N-262): sc-764 (A,B) and p-c-Myc (Thr 58/Ser 62)-R: sc-8000-R (C,D).
Western blot analysis of c-Myc expression in HeLa (A,D,F), Jurkat (B), K-562 (C) and NIH/3T3 (G) whole cell lysates and Jurkat (E,H) nuclear extracts. Antibodies tested include c-Myc (9E10): sc-40 (A-C), c-Myc (C-33): sc-42 (D,E) and c-Myc (N-262): sc-764 (F-H).
c-Myc (N-262): sc-764. Western blot analysis of c-Myc expression in COS (A) and Jurkat (B) whole cell lysates.
c-Myc (N-262): sc-764. Western blot analysis of c-Myc expression in non-transfected: sc-117752 (A) and mouse c-Myc transfected: sc-118892 (B) 293T whole cell lysates.
c-Myc (N-262): sc-764. Western blot analysis of c-Myc expression in non-transfected: sc-117752 (A) and human c-Myc transfected: sc-116671 (B) 293T whole cell lysates.
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