E12 Background Information Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. The E2A gene encodes two basic helix-loop-helix (bHLH) transcription factors, designated E12 and E47, produced by alternative splicing. E12 and E47 are nuclear proteins that form heterodimers with Myo D transcription factors and play a role in determining tissue-specific cell fate during embryogenesis. E12 and E47 bind to the kappa-E2 site in the kappa immunoglobulin gene enhancer.
E12 (H-208) Product Citations
See how others have used E12 (H-208): sc-762 antibody and or E12 (H-208) antibody conjugates.
