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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of CREB-2 of human origin
- recommended for detection of CREB-2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
- blocking peptide, sc-7583 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-7583 X, 200 µg/0.1 ml
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CREB-2 Background Information
Eukaryotic gene transcription is regulated by sequence-specific transcription factors which bind modular cis acting promotor and enhancer elements. The cAMP response element (CRE), one of the best studied of such elements, consists of the palindromic octanucleotide TGACGTCA. Several CRE binding proteins have been identified within the ATF/CREB family, the best characterized of which include CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3. These proteins share highly related COOH terminal leucine zipper dimerization and basic DNA binding domains but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins appear capable of binding CRE in its homodimeric form, certain of these also bind as heterodimers, both within the ATF/CREB family and even with members of the AP-1 transcription factor family.
| CREB-2 (C-19) Product Citations |
See how others have used CREB-2 (C-19): sc-7583 antibody and or CREB-2 (C-19) antibody conjugates.
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CREB-2 (C-19)
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CREB-2 (C-19): sc-7583. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
CREB-2 (C-19): sc-7583. Western blot analysis of CREB-2 expression in HeLa (A) and A-431 (B) whole cell lysates and A-431 nuclear extract (C).
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