ING1 Antibody (C-19): sc-7566

ING1 (Inhibitor of growth protein 1) is a 422 amino acid protein encoded by the human gene ING1. ING1 belongs to the ING family and contains one PHD-type zinc finger. ING1 cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene, ING1 is a nuclear protein with several known isoforms, three of which are designated p47ING1 (ING1 precursor), p33ING1 and p24ING1, whose expression varies per tissue. The p33ING1 isoform is expressed in all normal tissues and cells, while the p24ING1 isoform is expressed in testis, liver, and kidney, and is weakly expressed in colon and brain, but not in breast or cultured melanocytes.