epitope mapping near the C-terminus of Syntaxin 1A of human origin
recommended for detection of Syntaxin 1A, Syntaxin 1B, Syntaxin 2 and Syntaxin 3 of mouse, rat and human origin by ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
Syntaxin Background Information Correct vesicular transport is essential to the survival of eukaryotic cells. This process is determined by specific pairing of vesicle-associated SNAREs (v-SNAREs) with those on the target membrane (t-SNAREs). This complex then recruits soluble NSF attachment proteins (SNAPs) and N-ethylmaleimide-sensitive factor (NSF) to form the highly stable SNAP receptor (SNARE) complex. The formation of a SNARE complex pulls the vesicle and target membrane together and may provide the energy to drive fusion of the lipid bilayers. SNAPs, including a- and g-SNAP, are cytoplasmic proteins that bind to a membrane receptor complex composed of VAMP, SNAP 25 and Syntaxin. Syntaxins, a family of proteins involved in the fusion of synaptic vesicles with the plasma membrane, display broad tissue distribution and contain C-terminal hydrophobic domains that direct themselves to their respective intracellular compartments.
