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cyclin A (H-432) Antibody: sc-751 |
| Datasheet |
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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 1-432 representing full length cyclin A of human origin
- recommended for detection of cyclin A and cyclin A1 of mouse, rat and human origin by WB, IP, KA, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- agarose conjugate for IP studies, sc-751 AC, 500 µg/0.25 ml agarose
- fluorescein (sc-751 FITC) and rhodamine(sc-751 TRITC) conjugates for immunofluorescence, 200 µg/ml
- TransCruz reagent for ChIP application, sc-751 X, 200 µg/0.1 ml
- HRP conjugate, sc-751 HRP, 200 µg/ml
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
CCNA2 |
890 |
4q27 |
NM_001237 |
P20248
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123835 |
| Mouse |
Ccna2 |
12428 |
3 B |
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P51943
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N/A |
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cyclin A Background Information
The critical role that the family of regulatory proteins known as cyclins play in eukaryotic cell cycle regulation is well established. The best-characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of maturing promoting factor. Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin- dependent kinase-2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DRTF1 and E2F and retinoblastoma protein, p110. A second form of cyclin A, named cyclin A1 because of its high sequence homology to Xenopus cyclin A1, is most highly expressed in germ cells. It has been proposed that cyclin A1 can associate with Cdk2, p39 and Cdc2 p34.
| cyclin A (H-432) Product Citations |
See how others have used cyclin A (H-432): sc-751 antibody and or cyclin A (H-432) antibody conjugates.
323 total citations Loading citations.
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cyclin A (H-432)
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cyclin A (H-432): sc-751. Western blot analysis of cyclin A expression in MCF7 (A), SK-BR-3 (B), A-431 (C), HeLa (D) and U-937 (E) whole cell lysates.
cyclin A (H-432): sc-751. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing nuclear staining.
Western blot detection of cyclin A phosphorylation using A-431 cells treated with EGF. Blots were probed with cyclin A (H-432): sc-751 (A), p-cyclin A (Ser 154)-R: sc-12916-R preincubated with cognate phosphorylated peptide (B) and p-cyclin A (Ser 154)-R: sc-12916-R pre-incubated with cognate unphosphorylated peptide (C).
cyclin A (H-432): sc-751. Western blot analysis of cyclin A expression in untreated (A) and Flurbiprofen ( sc-202158) treated (B) Caco-2 whole cell lysates. Note down regulation of cyclin A expression in lane B. cyclin A (H-432): sc-751. Western blot analysis of cyclin A expression in HeLa (A), K-562 (B) and HuT 78 (C) whole cell lysates.
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