CD72 Antibody (H-7): sc-7483

CD72 Antibody (H-7) is a mouse monoclonal IgG1 antibody that detects CD72 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. CD72 is a crucial transmembrane glycoprotein that plays a significant role in the regulation of B cell activation, acting as a negative regulator from the pro-B cell stage through to mature B cells. CD72 (H-7) antibody helps researchers study CD72′s ability to modulate immune responses; CD72 contains an immunoreceptor tyrosine-based inhibition motif (ITIM) that, upon tyrosine phosphorylation, recruits SH2-containing phosphatases such as SHP-1, leading to the downregulation of cell activation. This regulatory mechanism is vital for maintaining immune homeostasis, as evidenced by studies showing that CD72-deficient mice exhibit hyperproliferative B cells, which can result in autoimmune conditions. The human CD72 gene is located on chromosome 9p13.3, underscoring its evolutionary conservation and functional significance across species. Anti-CD72 antibody (H-7) is an essential tool for researchers investigating the intricate balance of immune cell activation and regulation.

The preferred CD72 antibody is CD72 Antibody (G-5): sc-25265.