Nup35 Antibody (P-17): sc-74762

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The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nup35 (nucleoporin 35kDa), also known as mitotic phosphoprotein 44, Nup53, MP44 or NP44, is a 326 amino acid nuclear protein belonging to the Nup53 family and is a component of the nuclear pore complex. Nup35 localizes to the nuclear rim and is also known to associate with nuclear membrane and lamina. Containing one MPPN (mitotic phosphoprotein N' end) domain, Nup35 contains multiple phenylalanine-glycine repeats and phosphoserine and phosphothreonine residues. Known to interact with NDC1, Lamin B, Nup205, Nup155 and Nup93, Nup35 likely assists in associations between Mad 1 and NPC. The gene encoding Nup35 maps to human chromosome 2q32.1.