Dapper1 (D-19) Antibody: sc-74599

Dapper1 Background Information
Dapper1, also known as DACT1 (dapper, antagonist of beta-catenin, homolog 1), DPR1, HNG3 or FRODO, is an 836 amino acid protein that localizes to both the nucleus and the cytoplasm and contains a C-terminal PDZ-binding motif that is thought to mediate protein-protein interactions. Interacting with Dvl-2, Dapper1 functions to positively regulate Dvl-2-mediated developmental signaling pathways, specifically by preventing the degradation of ∫-catenin, thereby enhancing the transcriptional activation of select genes in the Wnt pathway. Dapper1 is downregulated in hepatocellular carcinoma, suggesting an additional role in tumor suppression. The gene encoding Dapper1 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder å1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.