IRF-7 Antibody (G-8): sc-74472

IRF-7 Antibody (G-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects IRF-7 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IRF-7 (G-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IRF-7 plays a crucial role in immune response by regulating type I interferons expression, which are vital for antiviral defense. IRF-7 is primarily located in the nucleus, where this transcription factor activates interferon-α and interferon-β genes expression in response to viral infections. Nuclear localization enables direct influence on cellular transcriptional machinery, enhancing interferon production to orchestrate immune response. Nuclear translocation upon activation underscores IRF-7′s importance in signaling pathways that mediate host defense against pathogens. Anti-IRF-7 antibody (G-8) enables researchers to gain insights into immune regulation mechanisms and interferon roles in antiviral immunity.

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IRF-7 Antibody (G-8) References:

1. Interferon regulatory factors: the next generation.  |  Mamane, Y., et al. 1999. Gene. 237: 1-14. PMID: 10524230
2. Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback.  |  Levy, DE., et al. 2002. J Interferon Cytokine Res. 22: 87-93. PMID: 11846979
3. Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit.  |  Ning, S., et al. 2003. J Virol. 77: 9359-68. PMID: 12915551
4. Kaposi's sarcoma-associated herpesvirus-encoded vIRF-3 stimulates the transcriptional activity of cellular IRF-3 and IRF-7.  |  Lubyova, B., et al. 2004. J Biol Chem. 279: 7643-54. PMID: 14668346
5. Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection.  |  Barnes, BJ., et al. 2004. J Biol Chem. 279: 45194-207. PMID: 15308637
6. Regulation of IRF7 through cell type-specific protein stability.  |  Prakash, A. and Levy, DE. 2006. Biochem Biophys Res Commun. 342: 50-6. PMID: 16472772
7. Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7.  |  Goubau, D., et al. 2009. Eur J Immunol. 39: 527-40. PMID: 19152337
8. Mechanisms of autoinhibition of IRF-7 and a probable model for inactivation of IRF-7 by Kaposi's sarcoma-associated herpesvirus protein ORF45.  |  Sathish, N., et al. 2011. J Biol Chem. 286: 746-56. PMID: 20980251
9. Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding.  |  De Ioannes, P., et al. 2011. Nucleic Acids Res. 39: 7300-7. PMID: 21596780
10. CCL7 and IRF-7 Mediate Hallmark Inflammatory and IFN Responses following Rhinovirus 1B Infection.  |  Girkin, J., et al. 2015. J Immunol. 194: 4924-30. PMID: 25847975
11. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.  |  Darnell, JE., et al. 1994. Science. 264: 1415-21. PMID: 8197455
12. IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency.  |  Zhang, L. and Pagano, JS. 1997. Mol Cell Biol. 17: 5748-57. PMID: 9315633

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IRF-7 Antibody (G-8) has 29 citations in a variety of scientific publications.

Primary antibodies like Anti-IRF-7 Antibody (G-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IRF-7 Antibody (G-8) Specifications

Alternate Product Name: IRF-7

Product Clone Name: G-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-246

Epitope Target: IRF-7

Epitope Species: human

Product Reactivity/Detection: IRF-7

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 29 citations in various scientific publications

Available Conjugates/Forms for IRF-7 Antibody (G-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent