epitope mapping within an internal region of Smad8 of rat origin
recommended for detection of Smad8 of mouse, rat and human origin by WB, IF and ELISA; non cross-reactive with Smad1 or Smad5; also reactive with additional species, including equine and canine
blocking peptide, sc-7442 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-7442 X, 200 µg/0.1 ml
Smad8 Background Information Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGF∫/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MADH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGF∫ and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGF∫ signaling by interfering with TGF∫-mediated phosphorylation of other Smad family members.
Smad8 (S-20) Product Citations
See how others have used Smad8 (S-20): sc-7442 antibody and or Smad8 (S-20) antibody conjugates.
