epitope mapping within an internal region of CAMTA1 of human origin
recommended for detection of CAMTA1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
TransCruz reagent for Gel Supershift and ChIP applications, sc-74353 X, 200 µg/0.1 ml
CAMTA1 Background Information The level of intracellular calcium is tightly regulated in all eukaryotic cells. A modest increase in this level can result in a myriad of physiological responses, most of which are mediated by calmodulin (CaM), the universal calcium sensor. CaM directly modulates the activity of protein kinases and phosphatases, ion channels and nitric oxide synthetases. CaM is generally involved in such diverse processes as cell proliferation, endocytosis, cellular adhesion, protein turnover and smooth muscle contraction. CAMTA1 (calmodulin binding transcription activator 1), also known as KIAA0833, is a 1,673 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one IPT/TIG domain, one CG-1 DNA-binding domain, three ANK repeats and three IQ domains. Expressed in brain tissue, as well as in heart and kidney, CAMTA1 interacts with CaM and is thought to function as a transcriptional activator, effecting the transcription level of target genes and possibly regulating CaM activity. Additionally, CAMTA1 may play a role in tumor suppression and, when defective, is involved in oligodendroglioma and astrocytoma.
