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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of HNF-1β of human origin
- recommended for detection of HNF-1β of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-7411 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-7411 X, 200 µg/0.1 ml
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HNF-1β Background Information
HNF-1 (a and b), HNF-3 (a, b and g), HNF-4 (a and g) and HNF-6 compose, in part, a homoeprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. HNF-3a, HNF-3b and HNF-3g regulate the transcription of numerous hepatocyte genes in adult liver. HNF-3a and HNF-3b have also been shown to be involved in gastrulation events such as body axis formation. HNF-4a and HNF-4g have been shown to be important for early embryo development. HNF-4a is expressed in liver, kidney, pancreas, small intestine, testis and colon; and HNF-4g is expressed in each of these tissues except liver. HNF-6 has been shown to bind to the promoter of HNF-3b, which indicates a potential role of HNF-6 in gut endoderm epithelial cell differentiation. Evidence suggests that HNF-6 may also be a transriptional activator for at least 22 other hepatocyte-enriched genes, including cytochrome P450 2C13 and a-1 antitrypsin.
| HNF-1β (C-20) Product Citations |
See how others have used HNF-1β (C-20): sc-7411 antibody and or HNF-1β (C-20) antibody conjugates.
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HNF-1β (C-20)
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HNF-1β (C-20): sc-7411. Western blot analysis of HNF-1β expression in non-transfected: sc-117752 (A) and human HNF-1β transfected: sc-113415 (B) 293T whole cell lysates. |
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