Lefty (M-20) Antibody: sc-7408

Lefty Background Information
The TGF∫ superfamily is composed of numerous growth and differentiation factors, including transforming growth factor (TGF) 1, 2 and 3; growth/differ-entiation factor (GDF) 1-9; Mullerian inhibiting substance (MIS); bone morpho-genic protein (BMP) 2-8; glial cell line-derived neurotrophic factor (GDNF); inhibins a, b-A, b-B and b-C; Lefty and Nodal. Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis. Lefty-A and Lefty-B are homologues of murine Lefty-1 and Lefty-2. Lefty-1 is required for left-right axis determination as a regulator of Lefty-2 and Nodal. It is a secreted protein expressed on the left side of developing embryos. The expression of Lefty-1 is mostly in the prospective floor plate (PFP), although weak expression can be seen in the lateral-plate mesoderm (LPM). It is involved in establishing left-right asymmetry of the organ systems of mammals. Lefty-A plays a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium.