epitope mapping at the N-terminus of BMP-5 of human origin
recommended for detection of BMP-5 and, to a lesser extent, BMP-6 and BMP-7 of mouse, rat and human origin by WB, IP, IF and ELISA; may cross-react with BMP-8; also reactive with additional species, including equine, canine, bovine, porcine and avian
BMP-5 Background Information Bone morphogenic proteins (BMPs) are members of the TGF∫ superfamily. BMPs are involved in the induction of cartilage and bone formation. In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation. Smad3 association with the TGF∫ receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway. BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation. BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs.
BMP-5 (N-19) Product Citations
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BMP-5 (N-19)
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BMP-5 (N-19): sc-7405. Western blot analysis of human recombinant BMP-5.
