Bcl-6 Background Information Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and Th1/Th2 differentiation. Bcl-6 negatively regulates NFkB expression, thereby inhibiting NFkB-mediated cellular functions. HDAC- and silent information regulator (SIR)-2-dependent acet-ylation of Bcl-6 causes downregulation of activity by inhibiting the ability of Bcl-6 to recruit complexes containing histone deacetylases (HDACs). Bcl-6 is frequently deregulated in non-Hodgkin’s B cell lymphomas. The human BCL6 gene has been shown to encode a protein of 706 amino acids.
Bcl-6 (D-8) Product Citations
See how others have used Bcl-6 (D-8): sc-7388 antibody and or Bcl-6 (D-8) antibody conjugates.
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Bcl-6 (D-8)
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Bcl-6 (D-8): sc-7388. Immunofluorescence staining of methanol-fixed BJAB cells showing nuclear localization (A). Immunoperoxidase staining of formalin-fixed, paraffin-embedded human pancreas tumor showing nuclear staining (B).
Bcl-6 (D-8): sc-7388. Western blot analysis of Bcl-6 expression in Ramos whole cell lysate.
Bcl-6 (D-8): sc-7388. Western blot analysis of Bcl-6 expression in Ramos whole cell lysate.
Bcl-6 (D-8): sc-7388. Western blot analysis of Bcl-6 expression in non-transfected 293T: sc-117752 (A), human Bcl-6 transfected 293T: sc-112850 (B) and Raji (C) whole cell lysates.
