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- mouse monoclonal IgG1; 200 µg/ml
- epitope corresponding to a domain 180 amino acids in length mapping near the N-terminus of Wilms’ tumor (WT1) of human origin
- recommended for detection of WT1 of mouse, rat and human origin by WB, IP and IF
- TransCruz reagent for Gel Supershift and ChIP applications, sc-7385 X, 200 µg/0.1 ml
- agarose conjugate for IP studies, sc-7385 AC, 500 µg/0.25 ml agarose
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WT1 Background Information
Wilms’ tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and, like retinoblastoma, is observed in both sporadic and inherited forms. The Wilms’ tumor locus has been mapped at chromosome 11p13 as a tumor suppressor gene which encodes a DNA binding protein with four zinc fingers and a glutamine-proline rich amino-terminus. The Wilms’ tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators. However, in contrast to Egr transcription factors, WT1 behaves as a transcriptional repressor in transient transfection assays with synthetic promotor constructs.
| WT1 (F-6) Product Citations |
See how others have used WT1 (F-6): sc-7385 antibody and or WT1 (F-6) antibody conjugates.
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WT1 (F-6)
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WT1 (F-6): sc-7385. Western blot analysis of WT1 expression in K-562 whole cell lysate.
WT1 (F-6): sc-7385. Western blot analysis of WT1 expression in non-transfected: sc-117752 (A) and truncated human WT1 transfected: sc-117178 (B) 293T whole cell lysates. |
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