GADD 153 Background Information GADD 153 has been described as a growth arrest and DNA damage-inducible gene that encodes a C/EBP-related nuclear protein. This protein has also been designated C/EBP-homologous protein (CHOP-10). GADD 153 expression is induced by a variety of cellular stresses, inducing nutrient deprivation and metabolic perturbations. GADD 153 functions to block cells in G1 to S phase in cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD 153 dimers away from “classical” C/EBP binding sites, recognizing instead unique “nonclassical” sites. Thus GADD 153 acts as a negative modulator of C/EBP-like proteins in certain terminally differentiated cells, similar to the regulatory function of Id on the activity of Myo D and Myo D-related proteins involved in the development of muscle cells.
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GADD 153 (B-3)
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GADD 153 (B-3): sc-7351. Western blot analysis of GADD 153 expression in cell lysates prepared from control (A) and LPS/PMA-treated (B) RAW 264.7 cells.
GADD 153 (B-3): sc-7351. Western blot analysis of GADD 153 expression in non-transfected: sc-117752 (A) and mouse GADD 153 transfected: sc-120383 (B) 293T whole cell lysates.
GADD 153 (B-3): sc-7351. Western blot analysis of GADD 153 expression in RAW 264.7 whole cell lysate.
GADD 153 (B-3): sc-7351. Western blot analysis of GADD 153 expression in non-transfected: sc-117752 (A) and human GADD 153 transfected: sc-177265 (B) 293T whole cell lysates.
Tubeimoside I: sc-204931. Immunofluorescence staining of methanol-fixed untreated (A) and HeLa cells treated with Tubeimoside I, showing increased expression of GADD 153 (B). Antibody tested: GADD 153 (B-3): sc-7351.
