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- rabbit polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of 14-3-3 γ of human origin
- recommended for detection of 14-3-3 γ and, to a lesser extent, 14-3-3 η of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-731 P
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14-3-3 γ Background Information
14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 b, g, e, z, h, q and s. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins; by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity, and facilitation of protein modification. Loss of expression contributes to a vast array of pathogenic cellular activities.
| 14-3-3 γ (C-16) Product Citations |
See how others have used 14-3-3 γ (C-16): sc-731 antibody and or 14-3-3 γ (C-16) antibody conjugates.
43 total citations Loading citations.
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14-3-3 γ (C-16)
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14-3-3 γ (C-16): sc-731. Western blot analysis of 14-3-3 γ expression in A-431 (A), K-562 (B), U-937 (C) and NIH/3T3 (D) whole cell lysates.
14-3-3 γ (C-16): sc-731. Immunofluorescence staining of methanol-fixed A-431 cells showing cytoplasmic localization.
14-3-3 γ (C-16): sc-731. Western blot analysis of 14-3-3 γ expression in non-transfected 293T: sc-117752 (A), human 14-3-3 γ transfected 293T: sc-113231 (B) and K-562 (C) whole cell lysates. 14-3-3 γ (C-16): sc-731. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing nuclear and cytoplasmic staining of cells in glomeruli and tubules (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
14-3-3 γ (C-16): sc-731. Western blot analysis of 14-3-3 η expression in non-transfected 293T: sc-117752 (A), mouse 14-3-3 η transfected 293T: sc-117813 (B) and NIH/3T3 (C) whole cell lysates. 14-3-3 γ (C-16): sc-731. Western blot analysis of 14-3-3 γ expression in non-transfected 293T: sc-117752 (A), human 14-3-3 γ transfected 293T: sc-113231 (B) and A-431 (C) whole cell lysates. 14-3-3 γ (C-16): sc-731. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic staining of myocyte cells.
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