SERCA1 Antibody (4i390): sc-73020

SERCA1 Antibody (4i390) is a mouse monoclonal IgG1 antibody that detects SERCA1 in mouse, rat, human, rabbit, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SERCA1, a member of the sarcoplasmic or endoplasmic reticulum calcium ATPase family, plays a crucial role in muscle physiology by mediating the uptake of calcium ions into the sarcoplasmic reticulum, which is essential for muscle contraction and relaxation. Proper functioning of SERCA1 is vital for maintaining low cytoplasmic calcium concentrations, thereby preventing excessive muscle contraction and ensuring efficient muscle relaxation. This regulation is particularly important in type II (fast) skeletal muscle, where SERCA1 is exclusively expressed, allowing for rapid and powerful muscle contractions. SERCA1′s activity is influenced by various post-translational modifications, which can affect function and stability, highlighting the importance of understanding these modifications in the context of muscle health and disease. Anti-SERCA1 antibody (4i390) is an invaluable tool for researchers studying calcium signaling and muscle physiology, providing insights into the mechanisms underlying muscle function and potential therapeutic targets for muscle-related disorders.

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SERCA1 Antibody (4i390) References:

1. Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 3 isoforms by steady-state and transient kinetic analyses.  |  Dode, L., et al. 2002. J Biol Chem. 277: 45579-91. PMID: 12207029
2. Dissection of the functional differences between sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) 1 and 2 isoforms and characterization of Darier disease (SERCA2) mutants by steady-state and transient kinetic analyses.  |  Dode, L., et al. 2003. J Biol Chem. 278: 47877-89. PMID: 12975374
3. Functional comparison between secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1 and sarcoplasmic reticulum Ca2+-ATPase (SERCA) 1 isoforms by steady-state and transient kinetic analyses.  |  Dode, L., et al. 2005. J Biol Chem. 280: 39124-34. PMID: 16192278
4. Tissue-specific expression of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPases (ATP2A/SERCA) 1, 2, 3 during Xenopus laevis development.  |  Pegoraro, C., et al. 2011. Gene Expr Patterns. 11: 122-8. PMID: 21074636
5. The key target of neuroprotection after the onset of ischemic stroke: secretory pathway Ca(2+)-ATPase 1.  |  Li, LH., et al. 2015. Neural Regen Res. 10: 1271-8. PMID: 26487855
6. Plasma membrane Ca2+ -ATPase 1 is required for maintaining atrial Ca2+ homeostasis and electrophysiological stability in the mouse.  |  Wang, Y., et al. 2017. J Physiol. 595: 7383-7398. PMID: 29023784
7. Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin.  |  Gong, D., et al. 2018. Nat Commun. 9: 3623. PMID: 30190470
8. Plasma membrane Ca2+ ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca2+ homeostasis in mice.  |  Korthals, M., et al. 2021. Eur J Immunol. 51: 594-602. PMID: 33098669
9. SERCA-1 conformational change exerted by the Ca2+-channel blocker diltiazem affects mammalian skeletal muscle function.  |  Jiménez-Garduño, A., et al. 2024. Cell Calcium. 119: 102852. PMID: 38412581
10. Identification of new small molecules for selective inhibition of SERCA 1 in patient-derived metastatic papillary thyroid cancer.  |  Kim, SM., et al. 2025. Br J Pharmacol.. PMID: 39924143

The preferred SERCA1/2/3 antibody is SERCA1/2/3 Antibody (B-7): sc-271669.