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home » Membrane Receptors » Neu Antibody / Neu Antibodies » Neu (F-11): sc-7301

Neu (F-11) Antibody: sc-7301

  |  Datasheet
  • mouse monoclonal IgG2a; 200 µg/ml
  • specific for an epitope mapping between amino acids 1220-1255 at the C-terminus of Neu of human origin
  • recommended for detection of Neu gp185 and, to a lesser extent, ErbB-4 of mouse, rat and human origin by WB, IP, IF, IHC(P), FCM and ELISA
  • blocking peptide, sc-7301 P
  • agarose conjugate for IP studies, sc-7301 AC, 500 µg/0.25 ml agarose
  • phycoerythrin conjugate for intracellular FCM, sc-7301 PE, 100 tests
 
Additional Neu Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   FCM  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ERBB2 2064 17q12 NM_001005862, NM_004448 P04626
 211980
Mouse Erbb2 13866 11 D P70424
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Neu (F-11) sc-7301 200 µg/ml $279
Neu (F-11) AC sc-7301 AC 500µg/ml, 25%ag $366
Neu (F-11) P sc-7301 P
(peptide)
 100 µg/0.5 ml $61
Neu (F-11) PE sc-7301 PE 100 tests in 2ml $303
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
SK-BR-3 Cell Lysate sc-2218 500 µg/200 µl $104
MCF7 Whole Cell Lysate sc-2206 500 µg/200 µl $104
T-47D Cell Lysate sc-2293 500 µg/200 µl $104
Neu (m): 293T Lysate sc-125694 100µg/200µl $205
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104

Neu Background Information
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3), and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Neu, a glycoprotein, undergoes transactivation upon hetero-dimerization with other EGF receptor family members. Neu heterodimerization with ErbB-3 recruits heregulin, which induces phosphoinositide (PI) 3-kinase activation. Activation of Neu potentiates tumor cell motility and protease secretion and invasion, and also modulates cell cycle checkpoint function, DNA repair and apoptotic responses. Amplification and/or overexpression of Neu occurs in 20-30% of breast carcinomas. Measurement of increased Neu expression can be a predictor of disease prognosis. Neu may also prove to be a promising target for therapeutic agents.

Neu (F-11) Product Citations
See how others have used Neu (F-11): sc-7301 antibody and or Neu (F-11) antibody conjugates.


8 total citations
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Neu (F-11)
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sc-7301
Western blot analysis of ErbB receptor expression in NIH/3T3 transfectants expressing between 105 and 106 molecules/cell of Neu (ErbB-2) (A,E), ErbB-3 (B,F) and ErbB-4 (C,G) and in NIH/3T3 (D,H) whole cell lysates. Antibodies tested include Neu (F-11): sc-7301 (A-D) and Neu (C-18): sc-284 (EH).
sc-7301
Neu (F-11) PE: sc-7301 PE. Intracellular FCM analysis of fixed and permeabilized HEL 92.1.7 cells. Black line histogram represents the isotype control, normal mouse IgG2a: sc-2867.
sc-7301
Neu (F-11): sc-7301. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue (A) and immunofluorescence staining of methanol-fixed NIH/3T3 cells transfected with Neu (B) showing membrane staining.
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