GSK3 alpha/beta Antibody (0011-A): sc-7291

GSK-3α/β Antibody (0011-A) is a mouse monoclonal IgG2a kappa light chain antibody that detects the GSK-3 alpha / beta protein of mouse, rat, human, canine, and Xenopus origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and flow cytometry (FCM). GSK-3α/β Antibody (0011-A) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Glycogen synthase kinase 3 (GSK-3) is a serine/threonine kinase that plays a crucial role in numerous signaling pathways, particularly those involved in glycogen metabolism and cellular adhesion, and has been linked to the pathogenesis of Alzheimer′s disease. GSK-3 exists in two isoforms, GSK-3α and GSK-3β, which differ in subcellular localization, with GSK-3α primarily found in the cytoplasm and GSK-3β localized in both the cytoplasm and nucleus. This differential localization is significant as GSK-3 may influence specific signaling pathways that each isoform regulates, thereby affecting cellular responses to various stimuli. GSK-3 phosphorylates Tau, a microtubule-associated protein that stabilizes microtubules in neurons. Hyperphosphorylation of Tau, which occurs in Alzheimer′s disease, is believed to lead to the formation of neurofibrillary tangles, a hallmark of the disease. Understanding the distinct roles of GSK-3α and GSK-3β in cellular processes can help elucidate contributions to neurodegenerative diseases and explore potential therapeutic targets.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GSK3 alpha/beta Antibody (0011-A) has 276 citations in a variety of scientific publications.

Primary antibodies like Anti-GSK3 alpha/beta Antibody (0011-A) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GSK3 alpha/beta Antibody (0011-A) Specifications

Alternate Product Name: GSK3

Product Clone Name: 0011-A

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-420

Epitope Target: GSK-3β

Epitope Species: Xenopus laevis

Product Reactivity/Detection: GSK-3α and GSK-3β

Species Reactivity/Detection: mouse, rat, human, canine, Xenopus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 276 citations in various scientific publications

Available Conjugates/Forms for GSK3 alpha/beta Antibody (0011-A): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin