p73α Background Information The p53 gene is a widely studied anti-oncogene, or tumor suppressor gene. The p53 gene product can act as a negative regulator of cell growth in response to DNA damage. Mutations and allelic loss of the p53 gene have been associated with malignant transformation in a wide variety of human tumors. p53 shares considerable sequence similarity with p73, a gene that maps to a region in chromosome 1 that is frequently deleted in neuroblastomas. However, p73 does not appear to be activated by DNA damaging agents. The p73 isoform p73å inhibits drug-induced apoptosis in small cell lung carcinoma cells, while the p73 isoform p73∫ promotes it. p73å also prevents Bax activation, mitochondrial dysfunction, caspase activation and is able to reduce apoptosis induced by the BH3-only protein PUMA (p53 up-regulated modulator of apoptosis). There is an equilibrium between p73å and p73∫, demonstrated by the fact that p73å inhibits the pro-apoptotic effect of p73∫.
p73α (C-17) Product Citations
See how others have used p73α (C-17): sc-7238 antibody and or p73α (C-17) antibody conjugates.
