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Nrf2 Antibody (C-20): sc-722

 |  Datasheet

(Based on data analysis)

  • Nrf2 Antibody (C-20) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope mapping at the C-terminus of Nrf2 of human origin
  • recommended for detection of Nrf2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine, bovine and porcine
  • blocking peptide, sc-722 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-722 X, 200 µg/0.1 ml
  • See 105 citations for Nrf2 Antibody (C-20)
 

See additional Nuclear Factor Erythroid 2-Related Factor Antibodies including Nuclear Factor Erythroid 2-Related Factor, Nrf1, Nrf2 and Nrf3.

Also see chemical Nrf2 Activators for functional analysis of cellular responses to Nrf2.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   Gel Shift   ChIP   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Nrf2 Antibody (C-20) sc-722 200 µg/ml $279
Nrf2 (C-20) P sc-722 P
(peptide)
100 µg/0.5 ml $61
Nrf2 Antibody (C-20) X sc-722 X 200 µg/0.1 ml $279
 CRISPR/Cas9 KO and HDR Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Nrf2 CRISPR/Cas9 KO Plasmid (h) sc-400017 20 µg $345
Nrf2 HDR Plasmid (h) sc-400017-HDR 20 µg $385
Nrf2 CRISPR/Cas9 KO Plasmid (m) sc-421869 20 µg $345
Nrf2 HDR Plasmid (m) sc-421869-HDR 20 µg $385
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Nrf2 siRNA (h) sc-37030 10 µM $258
Nrf2 siRNA (m) sc-37049 10 µM $258
Nrf2 siRNA (h2) sc-44332 10 µM $258
Nrf2 siRNA (r) sc-156128 10 µM $258
Nrf2 (h)-PR sc-37030-PR 10 µM, 20 µl $23
Nrf2 (m)-PR sc-37049-PR 10 µM, 20 µl $23
Nrf2 (h2)-PR sc-44332-PR 10 µM, 20 µl $23
Nrf2 (r)-PR sc-156128-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Nrf2 shRNA Plasmid (h) sc-37030-SH 20 µg $520
Nrf2 shRNA Plasmid (m) sc-37049-SH 20 µg $520
Nrf2 shRNA Plasmid (h2) sc-44332-SH 20 µg $520
Nrf2 shRNA Plasmid (r) sc-156128-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Nrf2 shRNA (h) Lentiviral Particles sc-37030-V 200 µl $625
Nrf2 shRNA (m) Lentiviral Particles sc-37049-V 200 µl $625
Nrf2 shRNA (h2) Lentiviral Particles sc-44332-V 200 µl $625
Nrf2 shRNA (r) Lentiviral Particles sc-156128-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
THP-1 nuclear extract sc-24963 250 µg/0.05 ml $143
Nrf2 (m): 293T Lysate sc-127242 100 µg/200 µl $205
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NFE2L2 4780 2q31.2 NM_006164 Q16236
600492
Mouse Nfe2l2 18024 2 C3 Q60795
N/A
 


The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK. It regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (Mares). A family of NF-E2- related proteins, which are collectively known as the Cap ‘n’ collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind Mare sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, Jun B and Jun D) to activate gene expression, specifically the detoxifying enzyme NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from its repressor protein, Keap1. The gene encoding human Nrf3 maps to chromosome 7p15.2. Nrf3 is highly expressed in placenta, B cells and monocytes.

Nrf2 Antibody (C-20) Product Citations
See how others have used Nrf2 Antibody (C-20) and or Nrf2 Antibody (C-20) conjugates.


105 total citations
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Nrf2 Antibody (C-20) Data
Click on image to enlarge
Nrf2 (C-20): sc-722. Immunoperoxidase staining of formalin-fixed, paraffin-embedded mouse kidney tissue showing nuclear localization.
Nrf2 (C-20): sc-722. Western blot analysis of Nrf2 expression in THP-1 nuclear extract.
Nrf2 (C-20): sc-722. Western blot analysis of Nrf2 expression in non-transfected 293T: sc-117752 (A), mouse Nrf2 transfected 293T: sc-127242 (B) and Jurkat (C) whole cell lysates.
Nrf2 (C-20): sc-722. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
Nrf2 (C-20): sc-722. Western blot analysis of Nrf2 expression in untreated (A) and Tunicamycin treated (B) Hep G2 whole cell lysates. Data kindly provided by Dr. Jun Hee Lee, University ofM ichigan.
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