epitope corresponding to amino acids 210-335 mapping at the C-terminus of c-Fos of human origin
recommended for detection of c-Fos of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
TransCruz reagent for Gel Supershift and ChIP applications, sc-7202 X, 200 µg/0.1 ml
c-Fos Background Information The c-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
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c-Fos (H-125)
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c-Fos (H-125): sc-7202. Western blot analysis of c-Fos expression in nuclear extracts prepared from untreated (A) and PMA-treated (B) Jurkat cells.
c-Fos (H-125): sc-7202. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.