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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 50-240 of Stat3 p92 of human origin
- recommended for detection of Stat3 p92 of mouse, rat, human, zebrafish and Xenopus origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- TransCruz reagent for Gel Supershift and ChIP applications, sc-7179 X, 200 µg/0.1 ml
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Stat3 Background Information
Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3∫ appears to be activated by both while Stat3å is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
| Stat3 (H-190) Product Citations |
See how others have used Stat3 (H-190): sc-7179 antibody and or Stat3 (H-190) antibody conjugates.
78 total citations Loading citations.
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Stat3 (H-190)
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Stat3 (H-190): sc-7179. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung tumor showing cytoplasmic and nuclear staining.
Stat3 (H-190): sc-7179. Western blot analysis of Stat3 expression in KNRK whole cell lysate.
Stat3 (H-190): sc-7179. Western blot analysis of Stat3 expression in non-transfected 293T: sc-117752 (A), human Stat3 transfected 293T: sc-177985 (B) and K-562 (C) whole cell lysates. Stat3 (H-190): sc-7179. Western blot analysis of Stat3 expression in non-transfected 293T: sc-117752 (A), mouse Stat3 transfected 293T: sc-126053 (B) and K-562 (C) whole cell lysates. Stat3 (H-190): sc-7179. Western blot analysis of Stat3 expression in IFNγ treated HeLa whole cell lysate.
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