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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 1-465 representing full length Smad1 of human origin
- recommended for detection of Smad1, Smad2, Smad3, Smad5 and Smad8 of mouse, rat, human, and, to a lesser extent, mink origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- TransCruz reagent for Gel Supershift and ChIP applications, sc-7153 X, 200 µg/0.1 ml
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Smad Background Information
Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGF∫/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MADH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGF∫ and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGF∫ signaling by interfering with TGF∫-mediated phosphorylation of other Smad family members.
| Smad (H-465) Product Citations |
See how others have used Smad (H-465): sc-7153 antibody and or Smad (H-465) antibody conjugates.
7 total citations Loading citations.
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Smad (H-465)
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Smad (H-465): sc-7153. Western blot analysis of Smad expression in NIH/3T3 (A), Mv 1 Lu (B) and ZR-75-1 (C) whole cell lysates.
Smad (H-465): sc-7153. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic localization.
Smad (H-465): sc-7153. Immunoperoxidase staining of formalin-fixed, paraffin-embedded mouse ovary tissue showing nuclear and cytoplasmic localization.
Smad (H-465): sc-7153. Immunoperoxidase staining of formalin fixed, paraffin-embedded human epididymis tissue showing cytoplasmic staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
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