Hep B xAg Antibody (6D456): sc-71239

Hep B xAg Antibody (6D456) is a mouse monoclonal IgG1 kappa light chain antibody that detects the x-antigen of Hepatitis B virus by western blotting (WB) and immunoprecipitation (IP). Hep B xAg (6D456) antibody is available in a non-conjugated form, specifically designed for researchers studying the Hepatitis B virus (HBV). The Hepatitis B virus is a member of the Hepadnavirus family and is known to cause significant liver inflammation, leading to symptoms such as vomiting, jaundice, and in severe cases, death. Among the various proteins associated with HBV, the X protein, represented by Hep B xAg, plays a crucial role in the pathogenesis of the virus. X protein is located in the nucleus of infected hepatocytes and is implicated in the development of hepatocellular carcinoma due to its ability to upregulate matrix metalloproteinases, which facilitate tumor invasion and metastasis. Understanding the function of X protein is vital for developing targeted therapies and improving diagnostic methods for HBV-related liver diseases. Hep B xAg (6D456) monoclonal antibody is an essential tool for researchers investigating the molecular mechanisms of HBV infection and its associated complications.

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Hep B xAg Antibody (6D456) References:

1. In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4(+) Th1-type T-cell clones in a hu-PBL-NOD/SCID mouse model.  |  Cao, T., et al. 2001. J Virol. 75: 11449-56. PMID: 11689626
2. HBcAg-specific cytokine production by CD4 T lymphocytes of children with acute and chronic hepatitis B.  |  Szkaradkiewicz, A., et al. 2003. Virus Res. 97: 127-33. PMID: 14602204
3. Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.  |  Chung, TW., et al. 2004. FASEB J. 18: 1123-5. PMID: 15132991
4. Exposure of RNA templates and encapsidation of spliced viral RNA are influenced by the arginine-rich domain of human hepatitis B virus core antigen (HBcAg 165-173).  |  Le Pogam, S., et al. 2005. J Virol. 79: 1871-87. PMID: 15650211
5. Epitopes recognized by antibodies to denatured core protein of hepatitis B virus.  |  Bichko, V., et al. 1993. Mol Immunol. 30: 221-31. PMID: 7679466
6. Identification of hepatitis B virus core protein regions exposed or internalized at the surface of HBcAg particles by scanning with monoclonal antibodies.  |  Pushko, P., et al. 1994. Virology. 202: 912-20. PMID: 8030252
7. The structure of the variable regions of mouse monoclonal antibodies to hepatitis B virus core antigen.  |  Skrivelis, V., et al. 1993. Scand J Immunol. 37: 637-43. PMID: 8316761
8. Differentiation of core gene products of the hepatitis B virus in infected liver tissue using monoclonal antibodies.  |  Naoumov, NV., et al. 1997. J Med Virol. 53: 127-38. PMID: 9334923

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Hep B xAg Antibody (6D456) has 2 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Hep B xAg Antibody (6D456) Specifications

Alternate Product Name: Hep B xAg

Product Clone Name: 6D456

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Hep B xAg

Epitope Species: Hep B

Product Reactivity/Detection: x-antigen

Species Reactivity/Detection: Hep B

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Hep B xAg Antibody (6D456): N/A