DP-1 Antibody (3F149): sc-70989
- DP-1 Antibody (3F149) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 83-204 of DP-1 of human origin
- recommended for detection of DP-1 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- m-IgG1 BP-HRP is the preferred secondary detection reagent for DP-1 Antibody (3F149) for WB and IHC(P) applications. This reagent is now offered in a bundle with DP-1 Antibody (3F149) (see ordering information below).
DP-1 Antibody (3F149) is a mouse monoclonal IgG1 antibody that detects DP-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. DP-1, or Dimerization Partner 1, plays a crucial role in the regulation of the cell cycle by forming heterodimers with E2F transcription factors, which are essential for the transcriptional activation of genes involved in cell proliferation. The interaction between DP-1 and E2F proteins is vital for the progression from G1 phase to S phase of the cell cycle, as DP-1 (3F149) antibody facilitates the expression of genes necessary for DNA synthesis and cell division. Dysregulation of this complex can lead to uncontrolled cell growth and is often implicated in various cancers, making the study of DP-1 and its interactions critical for understanding tumorigenesis. Anti-DP-1 antibody (3F149) serves as an invaluable tool for researchers investigating cell cycle regulation and its implications in cancer biology.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DP-1 Antibody (3F149) References:
- Upregulation of a raf kinase and a DP-1 family transcription factor in epidermal growth factor (EGF) stimulated filarial parasites. | Dissanayake, S. 2000. Int J Parasitol. 30: 1089-97. PMID: 10996327
- Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents. | Lu, K., et al. 2000. Cancer Chemother Pharmacol. 46: 293-304. PMID: 11052627
- Further studies on diplopodia. VI. Segregation of diplopod embryos from chickens heterozygous for both dp-1 and dp-3 genes. | Taylor, LW. 1974. Can J Genet Cytol. 16: 121-35. PMID: 4407166
- A phage-associated murein hydrolase in Streptococcus pneumoniae infected with bacteriophage Dp-1. | Garcia, P., et al. 1983. J Gen Microbiol. 129: 489-97. PMID: 6132961
- Mutually exclusive interaction of the adenovirus E4-6/7 protein and the retinoblastoma gene product with internal domains of E2F-1 and DP-1. | O'Connor, RJ. and Hearing, P. 1994. J Virol. 68: 6848-62. PMID: 7933066
- Regulation of adenovirus 12 E1A transcription: E2F and ATF motifs in the E1A promoter bind nuclear protein complexes including E2F1, DP-1, cyclin A and/or RB and mediate transcriptional (auto)activation. | Kirch, HC., et al. 1993. Cell Mol Biol Res. 39: 705-16. PMID: 7951410
- Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein. | Helin, K. and Harlow, E. 1994. J Virol. 68: 5027-35. PMID: 8035503
- Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1. | Wu, CL., et al. 1996. Mol Cell Biol. 16: 3698-706. PMID: 8668186
- Expression of the E2F-1/DP-1 transcription factor in murine development. | Tevosian, SG., et al. 1996. Cell Growth Differ. 7: 43-52. PMID: 8788032
- The lytic enzyme of the pneumococcal phage Dp-1: a chimeric lysin of intergeneric origin. | Sheehan, MM., et al. 1997. Mol Microbiol. 25: 717-25. PMID: 9379901
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DP-1 Antibody (3F149) | sc-70989 | 200 µg/ml | $322.00 | |||
DP-1 Antibody (3F149): m-IgG1 BP-HRP Bundle | sc-542613 | 200 µg Ab; 20 µg BP | $361.00 |